Cognitive impairment following high fat diet consumption is associated with brain inflammation

Authors

Paul J. Pistell, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, United States.
Christopher D. Morrison
Sunita Gupta
Alecia G. Knight
Jeffrey N. Keller
Donald K. Ingram
Annadora J. Bruce-Keller

Document Type

Article

Publication Date

2-26-2010

Abstract

C57Bl/6 mice were administered a high fat, Western diet (WD, 41% fat) or a very high fat lard diet (HFL, 60% fat), and evaluated for cognitive ability using the Stone T-maze and for biochemical markers of brain inflammation. WD consumption resulted in significantly increased body weight and astrocyte reactivity, but not impaired cognition, microglial reactivity, or heightened cytokine levels. HFL increased body weight, and impaired cognition, increased brain inflammation, and decreased BDNF. Collectively, these data suggest that while different diet formulations can increase body weight, the ability of high fat diets to disrupt cognition is linked to brain inflammation.

Publication Source (Journal or Book title)

Journal of neuroimmunology

First Page

25

Last Page

32

Recommended Citation

Pistell, P. J., Morrison, C. D., Gupta, S., Knight, A. G., Keller, J. N., Ingram, D. K., & Bruce-Keller, A. J. (2010). Cognitive impairment following high fat diet consumption is associated with brain inflammation. Journal of neuroimmunology, 219 (1-2), 25-32. https://doi.org/10.1016/j.jneuroim.2009.11.010