Title

Surfactant therapy after electroporation mediated muscle injury in vivo

Document Type

Conference Proceeding

Publication Date

12-1-2000

Abstract

High voltage electrical shock can produce extensive muscle and nerve tissue damage due to poration of cell membranes by electric field gradients in addition to thermal denaturation of biomolecules. We studied the therapeutic membrane sealing effect of the surfactant Poloxamer 188 on muscle tissue damage in vivo following non-thermal electrical injury in our rat hind limb model (DC-pulses, 150 V/cm) by radiotracer imaging. Poloxamer 188 surfactant injections (50 mg/kg) showed a significant decrease in radiotracer retention compared to control injections post-shock. The results indicate the importance of membrane permeabilization and the therapeutic potential of surfactant sealing in electrical shock victims.

Publication Source (Journal or Book title)

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

First Page

1983

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