Semester of Graduation

Spring 2018


Master of Science (MS)


Exercise Physiology

Document Type




PURPOSE: To explore the hematological differences in African-American athletes with sickle cell trait (SCT) and healthy controls (CON) before preseason camp and the changes that occur after a full season. METHODS: Sixteen (n=8 SCT; n=8 position matched, CON) NCAA Division 1 athletes (12 football, 2 each women’s soccer and volleyball) had blood drawn before preseason camp, after and at the end of the season, and analyzed for Hb electrophoresis (Hb-A, Hb-A2, Hb-S, and Hb-F), complete blood count with differential, chemistry panel 26, and prothrombin time, activity and international normalized ratio (INR). RESULTS: Baseline total Hb was similar between SCT and CON (mean±SD; 14.2±1.3 vs. 14.1±0.9g/dL, resp; P=0.87), and as expected, Hb-A was lower and Hb-A2 and Hb-S were higher in SCT than CON (P^3/mL, P^3/mL; P=0.09) amongst SCT compared to CON, respectively. Baseline amylase (99.4±25.4 vs. 72.9±18.8u/L; P=0.03), uric acid (6.8±1.7 vs. 5.5±0.8mg/dL; P=0.08), and creatinine (1.2±0.2 vs. 1.0±0.2mg/dL; P=0.07) were higher in SCT compared to CON. All Hb measures in SCT were similar after camp compared to baseline (P>0.33 for all). Baseline and position adjusted change in neutrophils were similar between SCT and CON (mean, 95%CI; -0.09, -2.06 to 1.89 vs. 0.36, -1.61 to 2.34cellsx10^3/mL, resp; P=0.77) from preseason to post-camp. Similarly, the adjusted change in lymphocytes was not different between SCT and CON (0.53, 0.01 to 1.05 vs. 0.15, -0.37 to 0.67, resp; P=0.40), however, total lymphocyte counts increased in SCT over the time from preseason to post-camp (PCONCLUSION: Despite major hematological differences due to SCT, very few changes occurred during the exhaustive, preseason camp and regular season at sea level.



Committee Chair

Johannsen, Neil

Available for download on Friday, April 05, 2019