Master of Science (MS)
Thiol-acrylate materials have been demonstrated to have therapeutic potential as biocompatible scaffolds for bone tissue regeneration due to their osteoconductivity, biodegradability, and well-suited mechanical properties. This study connects the mechanical properties and stability of thiol-acrylate polymer with cell adhesion and proliferation of human adipose derived stromal cells. The polymer presented in this study, trimethylolpropane ethoxylate triacrylate-co-trimethylolpropane tris (3-mercaptopropionate) (TMPeTA-co-TMPTMP), was synthesized by an amine-catalyzed Michael addition reaction. Physical, mechanical, and chemical characterizations were performed on the polymeric scaffold, followed by preliminary in vitro cytocompatibility tests. Live/dead staining assays showed significant differences in cell adhesion for TMPeTA (692 and 912 MW). Collectively, these results highlight the potential for these thiol-acrylate based polymers to be a versatile, biocompatible scaffold for bone tissue engineering applications.
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Forghani, Anoosha, "Fabrication And Characterization Of Thiol-Acrylate Based Polymer for Bone Tissue Engineering Application" (2016). LSU Master's Theses. 458.