Master of Science (MS)
Bio-degradable poly (l-lactic acid) (PLLA) scaffolds were prepared by using thermally induced phase separation (TIPS) method. A solution of PLLA-Dioxane was formed by dissolving PLLA in dehydrated 1,4-Dioxane at three wt/vol percentages, specifically 3, 7 and 10%. This PLLA-Dioxane solution was then frozen in borosilicate glass vials (5mL) at three cooling rates (1, 10 and 40 ˚C/min) in a commercially available controlled rate freezer (CRF). The frozen solution was freeze-dried to sublimate the Dioxane. The microstructural properties of the resulting PLLA scaffolds were determined utilizing Scanning Electron Microscopy (SEM) images and uni- axial compressive testing. The relationship between the wt/vol ratio of PLLA and Dioxane and the imposed cooling rates on the structural properties of PLLA scaffolds was determined. This same procedure was then repeated using a mixture of Dioxane and Ethanol. The volume of the mixture constituted 15% of Ethanol and 85% Dioxane.
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Idicula, George, "Synthesis Of Poly(L-Lactic Acid) Scaffolds From Dioxane/Ethanol Using Control Rate Freezing And Study Of Its Microstructural Properties" (2013). LSU Master's Theses. 2634.