Degree

Doctor of Philosophy (PhD)

Department

Department of Physics and Astronomy

Document Type

Dissertation

Abstract

This thesis describes various applications of magnetic resonance imaging pulse sequences to motor adaptation, cognitive aging, and brown adipose tissue detection. Magnetic resonance imaging provides a unique contrast mechanism that depends on the magnetic properties of the sample, and the resulting images can contain different kinds of information. In this thesis, two main types of sequences are used to image biological tissues. One sequence is a blood-oxygen level dependent (BOLD) functional magnetic resonance imaging technique, in which images are produced with a relatively high temporal resolution to assess oxygen movement in the brain. The other sequence utilizes intermolecular multiple quantum coherence (iMQC) that can image the correlation between fat and water protons, and hence distinguish brown fat from other tissues. Both sequences employ spatial encoding in addition to the raw signal creation, either from gradient pulses or 180° radiofrequency pulses.

Date

6-30-2020

Committee Chair

Carmichael, Owen

Available for download on Monday, June 21, 2027

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