Doctor of Philosophy (PhD)
Chapter 1 is an introduction to the design and synthesis of regioisomerically pure phthalocyanines, their properties and characterization. It also introduces various concepts adopted for improvement of phthalocyanines biocompatibility. Chapter 2 covers the design, synthesis, characterization, photophysical and in vitro biological evaluation of alpha-(trimethylamine)-zinc Pc-folate nanoparticles, synthesized via anion exchange procedure. The phthalocyanine folate exhibited increased aqueous solubility. Chapter 3 describes the synthesis and characterization of a PEGylated phthalocyanine. Pc-protein conjugation parameters using BSA as a model protein are determined. Using these parameters, Pcs are conjugated to a monoclonal and polyclonal antibody. The antibody and Pc-antibody conjugates are characterized, evaluated in vitro, and in vivo. Chapter 4 describes the synthesis of Pc analogs of a Pc-isothiocyanate. Alkyl, biotin and peptides with amino functional groups are conjugated to the template in an addition reaction. The targeted or non-targeted Pc and its analogs are characterized, evaluated in vitro, and in vivo. Chapter 5 describes the synthesis of regioisomerically pure mono- and cis-di-substituted Pcs. These serve as templates in an alkylation procedure for the synthesis of a series of isomerically pure compounds.
Document Availability at the Time of Submission
Student has submitted appropriate documentation to restrict access to LSU for 365 days after which the document will be released for worldwide access.
Okoth, Elizabeth Judith Akinyi, "Synthesis, Characterization and Biological Evaluation of Monoisomeric Zinc Phthalocyanines for Imaging and Photodynamic Therapy" (2017). LSU Doctoral Dissertations. 4302.
Vicente, M. Graҫa H