Doctor of Philosophy (PhD)
The stereoselective construction of the tricyclic ring system of asteriscanolide from cyclooctadiene has been achieved. The synthesis involves two main steps; the synthesis of the aldehyde precursor(5)and the titanium-mediated cabocyclization of 5 to make the three rings of 43 stereoselectively.
Document Availability at the Time of Submission
Release the entire work immediately for access worldwide.
Sherriff, Mohamed G., "The stereoselective synthesis of the butyrolactone-bridged [8-5-5] tricyclic ring systems of (+/-)-asteriscanolide via the titanium-mediated Hetero-Pauson-Khand reaction" (2005). LSU Doctoral Dissertations. 2454.