Bio-magnetic bead separator on glass chips using semi-encapsulated spiral electromagnets
A new planar bio-magnetic bead separator on a glass chip has been designed, fabricated and tested. The separator is composed of micromachined semi-encapsulated spiral electromagnets and fluid channels, which are separately fabricated and then bonded. The device was tested with super-paramagnetic beads of mean diameter 0.83 μm which were suspended in a buffered solution with solid concentration 10%. When a DC current of 300 mA was applied to the inductor, the bio-magnetic beads were successfully attached on the electromagnets, showing a functional capability as a magnetic bead separator. Using this separator, cells or cell fragments and magnetic beads bonded with protein or enzyme suspended in bio-buffer solutions can be successfully separated from their suspensions.
Publication Source (Journal or Book title)
International Conference on Solid-State Sensors and Actuators, Proceedings
Liakopoulos, T., Choi, J., & Ahn, C. (1997). Bio-magnetic bead separator on glass chips using semi-encapsulated spiral electromagnets. International Conference on Solid-State Sensors and Actuators, Proceedings, 1, 485-488. Retrieved from https://digitalcommons.lsu.edu/eecs_pubs/117