New magnetic bead-based, filterless bio-separator with planar electromagnet surfaces for integrated bio-detection systems
A new filterless bio-separator separating magnetic microbeads from a carrier fluid has been designed, fabricated, and characterized as a core component of biological cell sampling and detecting systems. To maximize the sampling capability, a planar electromagnet surface with a serpentine coil and semi-encapsulated permalloy has been realized. Using this bio-separator, antibody-coated magnetic beads have been successfully separated from the bio-buffer suspension solution and characterized in dynamic fluid flow. The magnetic characteristics of the bio-separator have been simulated and experimentally studied to establish and validate the design rules for fabrication. The realized filterless bio-separator has a high potential in biomedical and biological detection systems. It is especially useful in selective sampling and separation of small amounts of bio-molecules (e.g., antigen) for on-chip micro total analysis systems (μ-TAS) or remote detection systems.
Publication Source (Journal or Book title)
Sensors and Actuators, B: Chemical
Choi, J., Ahn, C., Bhansali, S., & Henderson, H. (2000). New magnetic bead-based, filterless bio-separator with planar electromagnet surfaces for integrated bio-detection systems. Sensors and Actuators, B: Chemical, 68 (1), 34-39. https://doi.org/10.1016/S0925-4005(00)00458-5