Title

Pulsed valve matrix-assisted ionization

Document Type

Article

Publication Date

5-21-2017

Abstract

© 2017 The Royal Society of Chemistry. We have developed a new ionization approach for matrix-assisted ionization with high temporal resolution using an electrically actuated pulsed valve. Matrix and analyte samples are deposited on a thin metal foil and placed at the inlet of an ambient ionization mass spectrometer. When the pulsed valve is actuated, a short puff of high pressure gas impinges on the foil and ejects particulate from the sample on the opposite side. Highly charged ions are formed from the particles at the mass spectrometer inlet. Using this source, multiply charged protein ions are produced within a selectable 4 second time window.

Publication Source (Journal or Book title)

Analyst

First Page

1672

Last Page

1675

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