Title
Highly efficient protein capture and enzyme reactor beds based on ultra-high-aspect- Ratio nanostructures (uharns)
Document Type
Conference Proceeding
Publication Date
1-1-2005
Abstract
Demonstrated here is a unique, and previously unreported, template-assisted polymerization pattern transfer method for the tailor-made fabrication of ultra-high-aspect-ratio (up to 1600:1) nanostructures (nanopillars) integrated into polymer-based MEMS devices. UHARN pillars are readily surface modified with proteins and aptamers via resist-free patterning methods to afford enzyme reactors and protein capture beds with unprecedented surface-to-volume ratios (from 1 × 104 cm-1 to up to 6 × 104 cm-1 versus ∼500 for open channels), resulting in rapid enzyme consumption of substrates and high efficiency capture of target analytes. Copyright © 2005 by the Transducer Research Foundation, Inc.
Publication Source (Journal or Book title)
Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences
First Page
1261
Last Page
1263
Recommended Citation
Chen, G., Bolivar, J., Soper, S., & McCarley, R. (2005). Highly efficient protein capture and enzyme reactor beds based on ultra-high-aspect- Ratio nanostructures (uharns). Micro Total Analysis Systems - Proceedings of MicroTAS 2005 Conference: 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences, 1, 1261-1263. Retrieved from https://repository.lsu.edu/chemistry_pubs/892