Functional template-derived poly(methyl methacrylate) nanopillars for solid-phase biological reactions

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A free-standing erect polymethyl methacrylate (PMMA) nanopillar that possess ultrahigh aspect ratio was fabricated with nondestructive surface functionalization technique for solid-phase biological reactions. Photopolymerization of monomer within nanometer-diameter, micrometer-tall pores of anodic aluminum oxide (AAO) templates led to the facile production of PMMA nanostructures that retain the shape and size of the template pores. The electron micrograph of PMMA pillars modified for 20 min using a direct-write UV photochemical patterning method consists of oxygen and carbon. Scanning Electron Microscopy (SEM) images for smallest nanopillar features size fabricated show no damage for exposure times of 20 min and also the production of maximum carboxylic acid surface density. The results show that the amount of substrate processes by enzymes immobilized to a surface with a fixed two-dimensional footprint can be increased by the use of PMMA nanopillar supports.

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Chemistry of Materials

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