Title

Efficacious fluorescence turn-on probe for high-contrast imaging of human cells overexpressing quinone reductase activity

Document Type

Article

Publication Date

1-1-2017

Abstract

© The Royal Society of Chemistry. We report a new turn-on substrate probe whose intense fluorescent reporter signature is selectively provided upon probe activation by the cancer-associated oxidoreductase, hNQO1. The extremely high fluorescence turn-on of the probe was utilized to generate fluorescence microscope images of hNQO1-expressing, tumor-derived colorectal and ovarian cancer cells with unprecedented positive signal-to-negative background ratios (PNRs), a key step toward probe application in guided surgical removal of diseased tissues.

Publication Source (Journal or Book title)

Chemical Communications

First Page

783

Last Page

786

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