Title
Efficacious fluorescence turn-on probe for high-contrast imaging of human cells overexpressing quinone reductase activity
Document Type
Article
Publication Date
1-1-2017
Abstract
© The Royal Society of Chemistry. We report a new turn-on substrate probe whose intense fluorescent reporter signature is selectively provided upon probe activation by the cancer-associated oxidoreductase, hNQO1. The extremely high fluorescence turn-on of the probe was utilized to generate fluorescence microscope images of hNQO1-expressing, tumor-derived colorectal and ovarian cancer cells with unprecedented positive signal-to-negative background ratios (PNRs), a key step toward probe application in guided surgical removal of diseased tissues.
Publication Source (Journal or Book title)
Chemical Communications
First Page
783
Last Page
786
Recommended Citation
Best, Q., Prasai, B., Rouillere, A., Johnson, A., & McCarley, R. (2017). Efficacious fluorescence turn-on probe for high-contrast imaging of human cells overexpressing quinone reductase activity. Chemical Communications, 53 (4), 783-786. https://doi.org/10.1039/C6CC08306D