NMR Difference Probe: A dual-coil probe for NMR difference spectroscopy
A unique probe designed to acquire nuclear magnetic resonance difference spectra of two samples is presented. The NMR Difference Probe contains two sample coils in a resonant circuit that switches between parallel excitation and serial acquisition to cancel common signals such as solvent peaks and impurities. Two samples containing a common analyte, acetonitrile, were used to demonstrate signal cancellation in a difference spectrum collected with a single pulse experiment. The cancellation was over 96% effective. The approach described has applications in the areas of solvent subtraction and spectral simplification. © 2002 Elsevier Science (USA).
Publication Source (Journal or Book title)
Journal of Magnetic Resonance
Macnaughtan, M., Hou, T., MacNamara, E., Santini, R., & Raftery, D. (2002). NMR Difference Probe: A dual-coil probe for NMR difference spectroscopy. Journal of Magnetic Resonance, 156 (1), 97-103. https://doi.org/10.1006/jmre.2002.2535