Title

NMR Difference Probe: A dual-coil probe for NMR difference spectroscopy

Document Type

Article

Publication Date

1-1-2002

Abstract

A unique probe designed to acquire nuclear magnetic resonance difference spectra of two samples is presented. The NMR Difference Probe contains two sample coils in a resonant circuit that switches between parallel excitation and serial acquisition to cancel common signals such as solvent peaks and impurities. Two samples containing a common analyte, acetonitrile, were used to demonstrate signal cancellation in a difference spectrum collected with a single pulse experiment. The cancellation was over 96% effective. The approach described has applications in the areas of solvent subtraction and spectral simplification. © 2002 Elsevier Science (USA).

Publication Source (Journal or Book title)

Journal of Magnetic Resonance

First Page

97

Last Page

103

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