Title

CDP-Ethanolamine and CDP-Choline: One-pot synthesis and 31P NMR study

Document Type

Article

Publication Date

9-17-2014

Abstract

© 2014 Elsevier Ltd. All rights reserved. Herein we report a one-pot multi-step synthesis of the cofactors CDP-Ethanolamine and CDP-Choline starting from cytidine 5′-monophosphate and using commercially available and/or easily prepared reagents. While studying the 31P NMR spectrum of CDP-Ethanolamine, an unexpected characteristic for a pyrophosphate diester was observed as it showed a singlet or two doublets depending upon the pH. Therefore, further NMR studies were undertaken to investigate the pH dependence of the peak splitting pattern and measure the acid dissociation constants of the compounds.

Publication Source (Journal or Book title)

Tetrahedron Letters

First Page

5306

Last Page

5310

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