Title

Electrophile-induced ether transfer: An expedient route to 2-cyano-tetrahydropyrans

Document Type

Article

Publication Date

12-31-2007

Abstract

Electrophile-induced ether transfer reactions of alkoxymethyl ether protected homoallylic alcohols with cyanide quench provide cyanoether adducts in high yield and excellent 1,3-syn-stereoselectivity. Subsequent base-mediated cyclization then provides the corresponding 2,4,6-trisubstituted cyano-tetrahydropyran. © 2007 The Japan Institute of Heterocyclic Chemistry.

Publication Source (Journal or Book title)

Heterocycles

First Page

447

Last Page

459

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