Electrophile-induced ether transfer: An expedient route to 2-cyano-tetrahydropyrans
Electrophile-induced ether transfer reactions of alkoxymethyl ether protected homoallylic alcohols with cyanide quench provide cyanoether adducts in high yield and excellent 1,3-syn-stereoselectivity. Subsequent base-mediated cyclization then provides the corresponding 2,4,6-trisubstituted cyano-tetrahydropyran. © 2007 The Japan Institute of Heterocyclic Chemistry.
Publication Source (Journal or Book title)
Kartika, R., & Taylor, R. (2007). Electrophile-induced ether transfer: An expedient route to 2-cyano-tetrahydropyrans. Heterocycles, 74 (C), 447-459. Retrieved from https://digitalcommons.lsu.edu/chemistry_pubs/583