Title

Concise enantioselective total synthesis of neopeltolide macrolactone highlighted by ether transfer

Document Type

Article

Publication Date

12-1-2008

Abstract

(Chemical Equation Presented) A concise total synthesis of neopeltolide macrolactone has been accomplished in 14 steps in the longest linear sequence, 15 steps overall from commercially available materials. The present synthesis was highlighted by successful exploitation of ether transfer methodology and a radical cyclization reaction to directly establish the requisite stereochemistry of the tetrahydropyran core. © 2008 American Chemical Society.

Publication Source (Journal or Book title)

Organic Letters

First Page

5047

Last Page

5050

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