Title

Chlorination of aliphatic primary alcohols via triphosgene-triethylamine activation

Document Type

Article

Publication Date

7-20-2012

Abstract

Activation of primary aliphatic alcohols with triphosgene and triethylamine mixtures afforded either alkyl chloride or diethylcarbamate products, and the switch in selectivity appeared to be driven by sterics. The reaction conditions to achieve this highly useful transformation were unexceptionally mild and readily tolerated by a wide range of sensitive functionalities. © 2012 American Chemical Society.

Publication Source (Journal or Book title)

Organic Letters

First Page

3676

Last Page

3679

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