Title

Triphosgene-pyridine mediated stereoselective chlorination of acyclic aliphatic 1,3-diols

Document Type

Article

Publication Date

8-14-2015

Abstract

© The Royal Society of Chemistry. We describe a strategy to chlorinate stereocomplementary acyclic aliphatic 1,3-diols using a mixture of triphosgene and pyridine. While 1,3-anti diols readily led to 1,3-anti dichlorides, 1,3-syn diols must be converted to 1,3-syn diol monosilylethers to access the corresponding 1,3-syn dichlorides. These dichlorination protocols were operationally simple, very mild, and readily tolerated by advanced synthetic intermediates.

Publication Source (Journal or Book title)

Chemical Communications

First Page

15075

Last Page

15078

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