Title

An expedient synthesis of functionalized 1,4-diketone-derived compounds via silyloxyallyl cation intermediates

Document Type

Article

Publication Date

2-7-2016

Abstract

© The Royal Society of Chemistry 2016. Herein we describe a new method, enabling the synthesis of highly functionalized 1,4-diketones that are readily differentiated as monosilylenol ethers under Brønsted acid catalysis. This synthetically useful chemistry exploited an intermediacy of unsymmetrical silyloxyallyl cations, which were directly captured by silyl enolates to create the targeted α,α carbon-carbon linkages in a regioselective manner. Our reaction conditions proved to be mild, rendering the silylenol ether functionalities intact.

Publication Source (Journal or Book title)

Chemical Communications

First Page

2300

Last Page

2303

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