Regioselective Functionalization of Enamides at the α-Carbon via Unsymmetrical 2-Amidoallyl Cations
© 2017 American Chemical Society. A new method to functionalize enamides via an intermediacy of unsymmetrical 2-amidoallyl cations is reported. Generated under mild Brønsted acid catalysis, these reactive species were found to undergo addition with various nucleophiles at the less substituted α-carbon to produce highly substituted enamides in high yields with complete control of regioselectivity.
Publication Source (Journal or Book title)
Saputra, M., Dange, N., Cleveland, A., Malone, J., Fronczek, F., & Kartika, R. (2017). Regioselective Functionalization of Enamides at the α-Carbon via Unsymmetrical 2-Amidoallyl Cations. Organic Letters, 19 (9), 2414-2417. https://doi.org/10.1021/acs.orglett.7b00962