Title

Regioselective Functionalization of Enamides at the α-Carbon via Unsymmetrical 2-Amidoallyl Cations

Document Type

Article

Publication Date

5-5-2017

Abstract

© 2017 American Chemical Society. A new method to functionalize enamides via an intermediacy of unsymmetrical 2-amidoallyl cations is reported. Generated under mild Brønsted acid catalysis, these reactive species were found to undergo addition with various nucleophiles at the less substituted α-carbon to produce highly substituted enamides in high yields with complete control of regioselectivity.

Publication Source (Journal or Book title)

Organic Letters

First Page

2414

Last Page

2417

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