Title
Regioselective Functionalization of Enamides at the α-Carbon via Unsymmetrical 2-Amidoallyl Cations
Document Type
Article
Publication Date
5-5-2017
Abstract
© 2017 American Chemical Society. A new method to functionalize enamides via an intermediacy of unsymmetrical 2-amidoallyl cations is reported. Generated under mild Brønsted acid catalysis, these reactive species were found to undergo addition with various nucleophiles at the less substituted α-carbon to produce highly substituted enamides in high yields with complete control of regioselectivity.
Publication Source (Journal or Book title)
Organic Letters
First Page
2414
Last Page
2417
Recommended Citation
Saputra, M., Dange, N., Cleveland, A., Malone, J., Fronczek, F., & Kartika, R. (2017). Regioselective Functionalization of Enamides at the α-Carbon via Unsymmetrical 2-Amidoallyl Cations. Organic Letters, 19 (9), 2414-2417. https://doi.org/10.1021/acs.orglett.7b00962