Title

Enantioselective Functionalization of Enamides at the β-Carbon Center with Indoles

Document Type

Article

Publication Date

11-19-2018

Abstract

© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim We report an enantioconvergent approach for the functionalization of enamides at the β-carbon atom, which involves a chiral Brønsted acid induced tautomerization of 2-amidoallyl into 1-amidoallyl cations. These putative reactive intermediates were produced by ionization of racemic α-hydroxy enamides with a chiral Brønsted acid and captured with substituted indoles in a highly regio- and enantioselective manner.

Publication Source (Journal or Book title)

Angewandte Chemie - International Edition

First Page

15558

Last Page

15562

This document is currently not available here.

Share

COinS