Title

Characterization of biological structures with nonlinear chemical imaging nanomicroscopy

Document Type

Conference Proceeding

Publication Date

1-1-2002

Abstract

Techniques of coherent nonlinear spectroscopy (second harmonic generation and third harmonic generation) are combined with near-field scanning optical microscopy for imaging selected chemical and physical environments in biological matter on a nanoscopic scale. Resonant enhancement of nonlinear signals is utilized as a method of producing chemically selective contrast while the order of the process provides environmental selectivity. Systems studied include natural killer cells and erythrocytes.

Publication Source (Journal or Book title)

Proceedings of SPIE - The International Society for Optical Engineering

First Page

62

Last Page

68

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