Manipulation and capture of Aβ amyloid fibrils and monomers by DC insulator gradient dielectrophoresis (DC-iGDEP)
Here we report a novel method for the manipulation and concentration of Aβ amyloid fibrils, implicated in Alzheimer's disease, using DC insulating gradient dielectrophoresis (DC-iGDEP). Fibril enrichment was found to be ∼400%. Simulations suggest that capture of the full range of amyloid protein aggregates is possible with optimized device design. © 2012 The Royal Society of Chemistry.
Publication Source (Journal or Book title)
Staton, S., Jones, P., Ku, G., Gilman, S., Kheterpal, I., & Hayes, M. (2012). Manipulation and capture of Aβ amyloid fibrils and monomers by DC insulator gradient dielectrophoresis (DC-iGDEP). Analyst, 137 (14), 3227-3229. https://doi.org/10.1039/c2an35138b