Title
Assignment of Absolute Configuration of a New Hepatoprotective Schiartane-Type Nortriterpenoid Using X-Ray Diffraction
Document Type
Article
Publication Date
1-2-2017
Abstract
A new schiartane-type nortriterpenoid, micrandilactone H was isolated from Finet et Gagnep. Its 2D (two dimension) structure was elucidated by NMR spectroscopic analysis, and it is similar to that of Kadnanolactones H and the absolute configuration was established through X-ray diffraction and ECD data analysis. This represents the first complete assignment of the absolute configuration of a schiartane-type nortriterpenoid by X-ray diffraction and the ECD method. Micrandilactone H showed moderate hepatoprotective activity against -acetyl--aminophenol (APAP)-induced toxicity in HepG2 cells with cell survival rates of 56.84% at 10 μM.
Publication Source (Journal or Book title)
Molecules (Basel, Switzerland)
Recommended Citation
Wang, X., Fronczek, F. R., Chen, J., Liu, J., Ferreira, D., Li, S., & Hamann, M. T. (2017). Assignment of Absolute Configuration of a New Hepatoprotective Schiartane-Type Nortriterpenoid Using X-Ray Diffraction. Molecules (Basel, Switzerland), 22 (1) https://doi.org/10.3390/molecules22010065