Title

Thermoresponsive poly(α-peptoid)s: Tuning the cloud point temperatures by composition and architecture

Document Type

Article

Publication Date

5-15-2012

Abstract

Random copolymers based on poly(N-ethyl glycine) and poly(N-butyl glycine) have been synthesized by NHC-mediated or primary amine-initiated copolymerization of the corresponding N-substituted N-carboxyanhydride monomers (i.e., Et-NCA and Bu-NCA), respectively. The copolymers are thermally responsive and exhibit reversible phase transitions with tunable cloud point temperature (Tcp) in aqueous solution. The Tcp can be readily tuned in the temperature range 20-60 °C by controlling the copoly(α-peptoid) composition and the architecture (i.e., cyclic vs linear). The copoly(α-peptoid)s are non-cytotoxic (similar to poly(ethylene glycol) (PEG), a benchmark biocompatible polymer), suggesting their potential use in biotechnology and biomedicine. (Figure presented) © 2012 American Chemical Society.

Publication Source (Journal or Book title)

ACS Macro Letters

First Page

580

Last Page

584

This document is currently not available here.

Share

COinS