Influence of Alcohols on the β-Cyclodextrin/Acridine Complex

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The apparent formation constant calculated for the β-cyclodextrin/acridine (β-CD/ACR) complex (287 M−1) reveals a weak association in aqueous solution. An additional weakening of the binding strength between β-CD and ACR, and subsequent reduction in the previously reported quenching of ACR caused by β-CD, is observed upon interaction of the complex with selected straight-chain and branched alcohols. Nuclear magnetic resonance data suggest that the equilibrium involves the formation of ternary complexes. This equilibrium apparently leaves a greater number of ACR species accessible to the bulk aqueous environment, resulting in a consequent decrease in the total amount of ACR quenched. Specific mechanisms of interaction are further examined through information provided by steady-state fluorescence and fluorescence lifetime analysis. © 1993, American Chemical Society. All rights reserved.

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Journal of the American Chemical Society

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