Title

Combined polymerized chiral micelle and γ-cyclodextrin for chiral separation in capillary electrophoresis

Document Type

Article

Publication Date

9-22-1995

Abstract

A combination of a polymerized chiral micelle, poly(sodium N-undecylenyl-d-valinate) [poly(d-SUV)] and γ-cyclodextrin (γ-CD) is used for the first time for chiral separation in capillary electrophoresis. A simple theory is presented to rationalize the synergistic effect of the enantioselectivity obtained by use of poly(d-SUV) and γ-CD in combination. A mixture of four enantiomeric pairs is successfully resolved by use of this combination. The resolutions of the enantiomers using this approach are far superior to those obtained by use of either poly(d-SUV) or γ-CD alone. In addition, the effects of the antipode (l-SUV), γ-CD concentration, buffer concentration, organic solvents, and urea concentration on the resolution are also examined. © 1995.

Publication Source (Journal or Book title)

Journal of Chromatography A

First Page

297

Last Page

304

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