Title

Studies of Polymerized Sodium N-Undecylenyl-L-valinate in Chiral Micellar Electrokinetic Capillary Chromatography of Neutral, Acidic, and Basic Compounds

Document Type

Article

Publication Date

1-1-1997

Abstract

The polymerized surfactant poly( sodium N-undecylenyl amino L-valinate) [poly(L-SUV)] has been used in micellar electrokinetic capillary chromatography for the chiral separation of various acidic and basic drugs, as well as neutral compounds. Under the conditions studied, poly-(L-SUV) was shown to be a very versatile anionic chiral selector in the pH range of 5.6-11. The micelle was used for the enantioseparation of coumarinic anticoagulant drugs with various buffers under moderately acidic conditions. Neutral and alkaline buffer conditions were used to successfully separate the neutral atropisomers (±)-1,1′-bi-2-naphthol, (±)-1,1′ -binaphthyl-2,2′-diamine, and Tröger's base. Chiral separation of the cationic paveroline drugs, laudanosine, norlaudanosoline, and laudanosoline, was influenced by pH and the use of coated capillaries. The acquired data focused on optimizing the migration times, capacity and separation factors, and electrophoretic mobilities of the various racemic mixtures.

Publication Source (Journal or Book title)

Analytical Chemistry

First Page

958

Last Page

964

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