Title
Cationic β-cyclodextrin derivative for chiral separations
Document Type
Article
Publication Date
4-17-1998
Abstract
A novel hepta-substituted β-cyclodextrin bearing the methoxyethylamine group linked to the upper cycloclextrin rim was successfully used as a chiral selector for enantiomeric separation of non-steroidal anti-inflammatory drugs (NSAIDs) and phenoxypropionic acid herbicides (PPAHs). Separation parameters such as pH and concentration were found to have major influences on enantiomeric resolution of the NSAIDs and PPAHs. Results indicate that heptakis(6-methoxyethylamine-6-deoxy)-β-cyclodextrin [β-CD-OMe (VII)] performs exceptionally well for the enantiomeric resolution of NSAIDs: indoprofen and fenoprofen (R8=11 and 14, respectively). In addition, baseline enantiomeric separation of a mixture of six pairs of PPAHs was achieved in under 30 min. Compared to other cationic β-cyclodextrins reported in the literature, the β-CD-OMe (VII) showed improved selectivity for both classes of the aforementioned anionic racemates.
Publication Source (Journal or Book title)
Journal of Chromatography A
First Page
261
Last Page
271
Recommended Citation
Haynes, J., Shamsi, S., O'Keefe, F., Darcey, R., & Warner, I. (1998). Cationic β-cyclodextrin derivative for chiral separations. Journal of Chromatography A, 803 (1-2), 261-271. https://doi.org/10.1016/S0021-9673(97)01212-0