Title

Comparison of monomeric and polymeric amino acid based surfactants for chiral separations

Document Type

Article

Publication Date

7-13-2001

Abstract

To better understand chiral recognition with polymeric amino acid based surfactants, the chromatographic performance of 18 monomeric and polymeric surfactants were compared for chiral analytes with various charge states and hydrophobicities. In this study, four amino acids (glycine, L-alanine, L-valine, and L-leucine) were chosen, and all possible combinations of the chiral single amino acid and dipeptide surfactants were synthesized. The results indicate that polymeric surfactants usually provide better chiral resolution for enantiomers of lorazepam, temazepam, 1,1′-bi-2-naphthol, and propranolol as compared to monomeric surfactants. In contrast, monomers perform better for chiral recognition of the 1,1′-bi-2-naphthyl-2,2′-diyl hydrogenphosphate enantiomers. © 2001 Elsevier Science B.V. All rights reserved.

Publication Source (Journal or Book title)

Journal of Chromatography A

First Page

329

Last Page

338

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