Title
Comparison of monomeric and polymeric amino acid based surfactants for chiral separations
Document Type
Article
Publication Date
7-13-2001
Abstract
To better understand chiral recognition with polymeric amino acid based surfactants, the chromatographic performance of 18 monomeric and polymeric surfactants were compared for chiral analytes with various charge states and hydrophobicities. In this study, four amino acids (glycine, L-alanine, L-valine, and L-leucine) were chosen, and all possible combinations of the chiral single amino acid and dipeptide surfactants were synthesized. The results indicate that polymeric surfactants usually provide better chiral resolution for enantiomers of lorazepam, temazepam, 1,1′-bi-2-naphthol, and propranolol as compared to monomeric surfactants. In contrast, monomers perform better for chiral recognition of the 1,1′-bi-2-naphthyl-2,2′-diyl hydrogenphosphate enantiomers. © 2001 Elsevier Science B.V. All rights reserved.
Publication Source (Journal or Book title)
Journal of Chromatography A
First Page
329
Last Page
338
Recommended Citation
Billiot, F., Billiot, E., & Warner, I. (2001). Comparison of monomeric and polymeric amino acid based surfactants for chiral separations. Journal of Chromatography A, 922 (1-2), 329-338. https://doi.org/10.1016/S0021-9673(01)00865-2