Chiral recognition of propranolol with β-cyclodextrin in the presence of 1- and 2-butanol
The purpose of this work is to investigate the chiral recognition characteristics of β-cyclodextrin with two propranolol enantiomers in the presence of organic additives. Steady-state fluorescence measurements of propranolol/β-cyclodextrin (β-CD) complexes were performed for solutions containing either 1- or 2-butanol. For each 2-butanol isomer solution, the interactions were assessed by comparing the changes in the fluorescence of (R)-(+)- propranolol versus (S)-(-)-propranolol as a function of CD concentration. A similar comparison study was done for the propranolol enantiomers in the presence of 1-butanol. The intensity changes for propranolol are relatively small upon addition of β-CD in the presence of the butanol alcohol. However, the present work shows that the interaction of (R)-(+)-propranolol with β-CD is influenced by the chirality of 2-butanol in contrast to (S)-(-)-propranolol. © Springer 2005.
Publication Source (Journal or Book title)
Journal of Inclusion Phenomena
Glenn, A., Fortier, C., Jack, I., Zhu, X., & Warner, I. (2005). Chiral recognition of propranolol with β-cyclodextrin in the presence of 1- and 2-butanol. Journal of Inclusion Phenomena, 51 (1), 87-91. https://doi.org/10.1007/s10847-004-5690-0