Title

Sodium Deoxycholate Hydrogels: Effects of Modifications on Gelation, Drug Release, and Nanotemplating

Document Type

Article

Publication Date

7-9-2015

Abstract

© 2015 American Chemical Society. In the present study, sodium deoxycholate (NaDC) was used to produce gelation of tris(hydroxymethyl)amino-methane (TRIS) solutions above, below, and near the pKa of NaDC, respectively, which yielded a neutral gelator, a charged gelator, and a mixture of each. Impacts of ionic interactions on gel formation were studied in detail and showed that pH can be used to modify many hydrogel properties including sol-gel temperature, crystallinity, and mechanical strength. Several formulations yielded a unique rheological finding of two stable regions of elastic modulus. The release of a small molecule has been investigated under different hydrogel conditions and at variable shear rate, suggesting utility as a drug-delivery vehicle. It was also observed that pH modification of the hydrogels affected nanoparticle formation. Nanoparticles derived from a Group of Uniform Materials Based on Organic Salts (nanoGUMBOS), specifically cyanine-based NIR dyes, were templated within the hydrogel network for potential applications in tissue imaging. These nanoGUMBOS were found to be size-tunable, although material-dependent. Further understanding of NaDC/TRIS gelation has broadened the tunability and multidimensional applications of these tailored hydrogel systems.(Figure Presented)

Publication Source (Journal or Book title)

Journal of Physical Chemistry B

First Page

8651

Last Page

8659

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