Meso-Tetraphenylporphyrin Dimer Derivative as a Potential Photosensitizer in Photodynamic Therapy
Studies on the synthesis, preliminary in vivo biological activity, singlet oxygen and fluorescence yields of a climeric porphyrin (D1) are described. The pharmacokinetic behavior and photodynamic properties of the dimer D1 were examined in Balb/c mice bearing an MS-2 fibrosarcoma. Compound D1 shows a high selectivity for tumor localization (tumor/peritumoral tissue ratios of dye concentration ranging between ca 100 and 140 at 24 h after drug administration of 5.0-1.0 mg kg-1 into DL-α-dipalmitoylphosphatidylcholine liposomes). The phototherapeutic efficiency of dimer D1 was evaluated by following the growth curves of fibrosarcoma irradiated with red light (600-700 nm) with a total dose of 400 J cm-2, at 24 h after intravenous injection. Photodynamic therapy-treated tumors showed a significant delay in growth as compared to untreated control mice. The results obtained suggest that the porphyrin dimer D1 may be a promising candidate for further use in PDT experiments.
Publication Source (Journal or Book title)
Photochemistry and Photobiology
Faustino, M., Neves, M., Vicente, M., Cavaleiro, J., Neumann, M., Brauer, H., & Jori, G. (1997). Meso-Tetraphenylporphyrin Dimer Derivative as a Potential Photosensitizer in Photodynamic Therapy. Photochemistry and Photobiology, 66 (4), 405-412. https://doi.org/10.1111/j.1751-1097.1997.tb03165.x