Title
Meso-Tetraphenylporphyrin Dimer Derivative as a Potential Photosensitizer in Photodynamic Therapy
Document Type
Article
Publication Date
1-1-1997
Abstract
Studies on the synthesis, preliminary in vivo biological activity, singlet oxygen and fluorescence yields of a climeric porphyrin (D1) are described. The pharmacokinetic behavior and photodynamic properties of the dimer D1 were examined in Balb/c mice bearing an MS-2 fibrosarcoma. Compound D1 shows a high selectivity for tumor localization (tumor/peritumoral tissue ratios of dye concentration ranging between ca 100 and 140 at 24 h after drug administration of 5.0-1.0 mg kg-1 into DL-α-dipalmitoylphosphatidylcholine liposomes). The phototherapeutic efficiency of dimer D1 was evaluated by following the growth curves of fibrosarcoma irradiated with red light (600-700 nm) with a total dose of 400 J cm-2, at 24 h after intravenous injection. Photodynamic therapy-treated tumors showed a significant delay in growth as compared to untreated control mice. The results obtained suggest that the porphyrin dimer D1 may be a promising candidate for further use in PDT experiments.
Publication Source (Journal or Book title)
Photochemistry and Photobiology
First Page
405
Last Page
412
Recommended Citation
Faustino, M., Neves, M., Vicente, M., Cavaleiro, J., Neumann, M., Brauer, H., & Jori, G. (1997). Meso-Tetraphenylporphyrin Dimer Derivative as a Potential Photosensitizer in Photodynamic Therapy. Photochemistry and Photobiology, 66 (4), 405-412. https://doi.org/10.1111/j.1751-1097.1997.tb03165.x