Improved synthesis of functionalized 2,2′-bipyrroles
(Chemical Equation Presented) A series of 2,2′-bipyrroles has been efficiently synthesized using an improved synthetic approach based on Pd(0-catalyzed homocoupling of various 2-iodopyrroles. This new synthetic approach takes place at room temperature and in the presence of water. Functional groups such as formyl, ester, and nitrile are able to survive these reaction conditions. Solvents are found to play an important role in this reaction. © 2007 American Chemical Society.
Publication Source (Journal or Book title)
Journal of Organic Chemistry
Jiao, L., Hao, E., Vicente, M., & Smith, K. (2007). Improved synthesis of functionalized 2,2′-bipyrroles. Journal of Organic Chemistry, 72 (21), 8119-8122. https://doi.org/10.1021/jo701310k