Synthesis and toxicity of cobaltabisdicarbollide-containing porphyrins of high boron content
Two porphyrins of high boron content (OCP and HCPPEG) were prepared in high yields from the reaction of the corresponding tri- and tetra-(dihydroxyphenyl) porphyrins with zwitterionic cobaltabisdicarbollide [3,3′-Co(8-C 4H8O2-1,2-C2B9H 10)(1′,2′-C2B9H11)]. Both porphyrins were found to have low cytotoxicity toward human HEp2 cells, and to localize subcellularly mainly in the cell lysosomes. Animal toxicity investigations using male and female BALB/c mice also revealed low toxicity for both compounds. The determined maximum tolerated dose (MTD) for these boronated porphyrins administered intraperitoneally were 160 mg/kg for OCP and 320 mg/kg for HCPPEG. Our studies warrant further development of these porphyrins of high boron content, and in particular of HCPPEG, as boron delivery vehicles for BNCT. © 2011 World Scientific Publishing Company.
Publication Source (Journal or Book title)
Journal of Porphyrins and Phthalocyanines
Bhupathiraju, N., Gottumukkala, V., Hao, E., Hu, X., Fronczek, F., Baker, D., Wakamatsu, N., & Vicente, M. (2011). Synthesis and toxicity of cobaltabisdicarbollide-containing porphyrins of high boron content. Journal of Porphyrins and Phthalocyanines, 15 (9-10), 973-983. https://doi.org/10.1142/S1088424611003902