Title

Synthesis and toxicity of cobaltabisdicarbollide-containing porphyrins of high boron content

Document Type

Article

Publication Date

1-1-2011

Abstract

Two porphyrins of high boron content (OCP and HCPPEG) were prepared in high yields from the reaction of the corresponding tri- and tetra-(dihydroxyphenyl) porphyrins with zwitterionic cobaltabisdicarbollide [3,3′-Co(8-C 4H8O2-1,2-C2B9H 10)(1′,2′-C2B9H11)]. Both porphyrins were found to have low cytotoxicity toward human HEp2 cells, and to localize subcellularly mainly in the cell lysosomes. Animal toxicity investigations using male and female BALB/c mice also revealed low toxicity for both compounds. The determined maximum tolerated dose (MTD) for these boronated porphyrins administered intraperitoneally were 160 mg/kg for OCP and 320 mg/kg for HCPPEG. Our studies warrant further development of these porphyrins of high boron content, and in particular of HCPPEG, as boron delivery vehicles for BNCT. © 2011 World Scientific Publishing Company.

Publication Source (Journal or Book title)

Journal of Porphyrins and Phthalocyanines

First Page

973

Last Page

983

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