Title

Syntheses, properties and cellular studies of metallo-isoporphyrins

Document Type

Article

Publication Date

1-1-2011

Abstract

b-Bilene hydrochlorides are shown to be improved intermediates for the synthesis of metallo-isoporphyrins in enhanced yields (28% vs. 6%). Several new diamagnetic zinc(II) and a novel paramagnetic copper(II) isoporphyrin salts were also obtained using this approach. Metal-free isoporphyrins were also isolated. In vitro studies using human carcinoma HEp2 cells show that all metallo-isoporphyrins accumulate within cells and localize partially in the mitochondria. The zinc-isoporphyrins were found to be moderately phototoxic while the copper complex showed the lowest phototoxicity, maybe as a result of its paramagnetic nature. © 2011 World Scientific Publishing Company.

Publication Source (Journal or Book title)

Journal of Porphyrins and Phthalocyanines

First Page

918

Last Page

929

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