Syntheses and properties of trimethylaminophenoxy-substituted Zn(ii)-phthalocyanines
The syntheses, photophysical properties and in vitro biological behavior of a series of nine Zn(ii)-phthalocyanines (ZnPcs) bearing one to eight positively-charged trimethylaminophenoxy groups are reported. All ZnPcs are highly soluble in polar organic solvents, and show fluorescence and singlet oxygen quantum yields in the ranges 0.11-0.21 and 0.16-0.47, respectively. The cytotoxicity of the ZnPcs depends on both the number of charges and their site of substitution (α vs. β) on the Pc isoindole units; the most promising for PDT application are the α-substituted di-cationic ZnPcs 6a and 17a. © 2012 The Royal Society of Chemistry.
Publication Source (Journal or Book title)
Ongarora, B., Hu, X., Li, H., Fronczek, F., & Vicente, M. (2012). Syntheses and properties of trimethylaminophenoxy-substituted Zn(ii)-phthalocyanines. MedChemComm, 3 (2), 179-194. https://doi.org/10.1039/c1md00232e