Title

Syntheses and properties of trimethylaminophenoxy-substituted Zn(ii)-phthalocyanines

Document Type

Article

Publication Date

2-1-2012

Abstract

The syntheses, photophysical properties and in vitro biological behavior of a series of nine Zn(ii)-phthalocyanines (ZnPcs) bearing one to eight positively-charged trimethylaminophenoxy groups are reported. All ZnPcs are highly soluble in polar organic solvents, and show fluorescence and singlet oxygen quantum yields in the ranges 0.11-0.21 and 0.16-0.47, respectively. The cytotoxicity of the ZnPcs depends on both the number of charges and their site of substitution (α vs. β) on the Pc isoindole units; the most promising for PDT application are the α-substituted di-cationic ZnPcs 6a and 17a. © 2012 The Royal Society of Chemistry.

Publication Source (Journal or Book title)

MedChemComm

First Page

179

Last Page

194

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