Title
Design and synthesis of photosensitizer-peptide conjugates for PDT
Document Type
Article
Publication Date
6-1-2016
Abstract
© 2016 by World Scientific Publishing Co. Pte. Ltd. The design and synthesis of covalently linked photosensitizer-peptide conjugates are reviewed in this chapter. Peptides of relatively small size (<50 amino acids) are most commonly used for enhancing the photosensitizer targeting specificity, due to their straightforward synthesis and ease of conjugation to photosensitizers. Porphyrin, chlorin and phthalocyanine macrocycles are the most common PDT photosensitizers used in the conjugation reactions to peptides, generally via a low molecular weight linker, following either solution or solid phase protocols. These so-called thirdgeneration photosensitizers have shown increased selectivity for targeting specific cell enzymes or receptors, and enhanced PDT efficacy compared with unconjugated photosensitizers.
Publication Source (Journal or Book title)
Handbook of Photodynamic Therapy: Updates on Recent Applications of Porphyrin-Based Compounds
First Page
45
Last Page
94
Recommended Citation
Williams, T., Sibrian-Vazquez, M., & Vicente, M. (2016). Design and synthesis of photosensitizer-peptide conjugates for PDT. Handbook of Photodynamic Therapy: Updates on Recent Applications of Porphyrin-Based Compounds, 45-94. https://doi.org/10.1142/9789814719650_0002