Synthesis of highly water soluble tetrabenzoporphyrins and their application toward photodynamic therapy
© 2020 World Scientific Publishing Company. Novel tetraaryl-(pyridinium-4-yl)-tetrabenzoporphyrins have been successfully synthesized via a Heck-based sequence reaction. These tetrabenzoporphyrins were substituted with eight pyridyl groups at the fused benzene rings. Methylation of the pyridyl groups with methyl iodide afforded highly water soluble tetrabenzoporphyrins carrying eight ionic groups. The extended π-conjugation broadened and red-shifted the absorption band of these porphyrins to 650-750 nm. These cationic tetrabenzoporphyrins showed non-toxicity in the dark up to 100 uM. High phototoxicity with IC50 values lower than 18 μM were obtained for these tetrabenzoporphyrins.
Publication Source (Journal or Book title)
Journal of Porphyrins and Phthalocyanines
Moss, A., Zhou, Z., Jiang, L., Vicente, M., & Wang, H. (2020). Synthesis of highly water soluble tetrabenzoporphyrins and their application toward photodynamic therapy. Journal of Porphyrins and Phthalocyanines, 24 (1-3), 456-464. https://doi.org/10.1142/S1088424619501785