Title

Functional ion channels in tethered bilayer membranes - Implications for biosensors

Document Type

Article

Publication Date

7-23-2007

Abstract

The ties that bind. A biosensor based on modulation of single ion-channel activity, with the ability to detect analytes in the micromolar range was devised. Ion channels were interfaced to a gold surface and reconstituted into tethered bilayer lipid membranes (tBLMs; see scheme). Using this method we obtained single channel activities from the synthetic ion channel, M2δ, and the Ca2+-activated K+ ion channel. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

Publication Source (Journal or Book title)

ChemBioChem

First Page

1246

Last Page

1250

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