Title
Functional ion channels in tethered bilayer membranes - Implications for biosensors
Document Type
Article
Publication Date
7-23-2007
Abstract
The ties that bind. A biosensor based on modulation of single ion-channel activity, with the ability to detect analytes in the micromolar range was devised. Ion channels were interfaced to a gold surface and reconstituted into tethered bilayer lipid membranes (tBLMs; see scheme). Using this method we obtained single channel activities from the synthetic ion channel, M2δ, and the Ca2+-activated K+ ion channel. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
Publication Source (Journal or Book title)
ChemBioChem
First Page
1246
Last Page
1250
Recommended Citation
Keizer, H., Dorvel, B., Andersson, M., Fine, D., Price, R., Long, J., Dodabalapur, A., Köper, I., Knoll, W., Anderson, P., & Duran, R. (2007). Functional ion channels in tethered bilayer membranes - Implications for biosensors. ChemBioChem, 8 (11), 1246-1250. https://doi.org/10.1002/cbic.200700094