Functional ion channels in tethered bilayer membranes - Implications for biosensors
The ties that bind. A biosensor based on modulation of single ion-channel activity, with the ability to detect analytes in the micromolar range was devised. Ion channels were interfaced to a gold surface and reconstituted into tethered bilayer lipid membranes (tBLMs; see scheme). Using this method we obtained single channel activities from the synthetic ion channel, M2δ, and the Ca2+-activated K+ ion channel. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
Publication Source (Journal or Book title)
Keizer, H., Dorvel, B., Andersson, M., Fine, D., Price, R., Long, J., Dodabalapur, A., Köper, I., Knoll, W., Anderson, P., & Duran, R. (2007). Functional ion channels in tethered bilayer membranes - Implications for biosensors. ChemBioChem, 8 (11), 1246-1250. https://doi.org/10.1002/cbic.200700094