Title
Molecular imprinting of carboxylic acids employing novel functional macroporous polymers
Document Type
Article
Publication Date
6-25-1999
Abstract
Imprinted network polymers incorporating basic functional groups were developed to assess the binding and specificity of carboxylic acids. The binding affinities were determined using t-BOC-phenylalanine and 2- phenylbutyric acid as templates and substrates. Chiral selectivity for the enantiomers of t-BOC-phenylalanine was found for polymers incorporating adenine or 2-aminopyridine functionality. Chiral selectivity in the case of (R)-(-)-2-phenylbutyric acid was found for the polymer utilizing N-(2- aminoethyl) methacrylamide as the functional monomer. Optimization of binding was achieved by changing polymerization conditions (thermal versus photochemical polymerization, monomer:template ratio) for t-BOC-phenylalanine imprinted polymers employing the N-(2-aminopyridine) methacrylamide monomer.
Publication Source (Journal or Book title)
Journal of Organic Chemistry
First Page
4627
Last Page
4634
Recommended Citation
Spivak, D., & Shea, K. (1999). Molecular imprinting of carboxylic acids employing novel functional macroporous polymers. Journal of Organic Chemistry, 64 (13), 4627-4634. https://doi.org/10.1021/jo982118s