Title
Absolute configuration determination using enantiomeric pairs of molecularly imprinted polymers
Document Type
Article
Publication Date
3-7-2014
Abstract
A new method for determination of absolute configuration (AC) is demonstrated using an enantiomeric pair of molecularly imprinted polymers, referred to as "DuoMIPs". The ratio of HPLC capacity factors (k′) for the analyte on each of the DuoMIPs is defined as the γ factor and can be used to determine AC when above 1.2. A mnemonic based on the complementary binding geometry of the DuoMIPs was used to aid in understanding and prediction of AC. © 2014 American Chemical Society.
Publication Source (Journal or Book title)
Organic Letters
First Page
1402
Last Page
1405
Recommended Citation
Meador, D., & Spivak, D. (2014). Absolute configuration determination using enantiomeric pairs of molecularly imprinted polymers. Organic Letters, 16 (5), 1402-1405. https://doi.org/10.1021/ol500173y