Title

Absolute configuration determination using enantiomeric pairs of molecularly imprinted polymers

Document Type

Article

Publication Date

3-7-2014

Abstract

A new method for determination of absolute configuration (AC) is demonstrated using an enantiomeric pair of molecularly imprinted polymers, referred to as "DuoMIPs". The ratio of HPLC capacity factors (k′) for the analyte on each of the DuoMIPs is defined as the γ factor and can be used to determine AC when above 1.2. A mnemonic based on the complementary binding geometry of the DuoMIPs was used to aid in understanding and prediction of AC. © 2014 American Chemical Society.

Publication Source (Journal or Book title)

Organic Letters

First Page

1402

Last Page

1405

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