Title

Pyrroles and related compounds. Part 38. Porphobilinogen synthesis 2

Document Type

Article

Publication Date

12-1-1977

Abstract

A new synthesis of porphobilinogen (1) and its [6-13C]- and [6-14C]-derivatives, via porphobilinogen lactam, is reported. For the most part the synthesis follows established methods in pyrrole chemistry, but there are two significant advances which make the route attractive: (1) transformation of readily available acetylpyrroles into methoxycarbonylmethylpyrroles by using thallium(III) nitrate in methanol, and (2) introduction of the aminomethyl function into porphobilinogen by cleavage of a phthalimidomethyl substituent.

Publication Source (Journal or Book title)

Journal of the Chemical Society, Perkin Transactions 1

First Page

332

Last Page

340

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