Title

Meso (Methine) functionalization of octa-alkylporphyrins

Document Type

Article

Publication Date

12-1-1981

Abstract

meso-Acetoxymethylocta-alkylporphyrins [e.g. (1), (7), and (8)] react with a variety of nucleophiles such as alcohols (to give the corresponding alkoxymethylporphyrins), amines (yielding aminomethylporphyrins), and Grignard reagents (to give meso-alkylporphyrins). Treatment of the meso- acetoxymethylporphyrins with thiol reagents accomplishes reduction to give the meso-methylporphyrin rather than the sulphide. Making use of these meso-functionalization reactions, potential cytochrome P450 models and a model for the tense form of hemoglobin are synthesized.

Publication Source (Journal or Book title)

Journal of the Chemical Society, Perkin Transactions 1

First Page

2625

Last Page

2630

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