Title
Synthetic approaches to versatile hemoprotein model compounds built from porphyrins and peptides
Document Type
Article
Publication Date
1-1-1982
Abstract
Several strategies for the preparation of mono- and bi-functional porphyrins (amino and carboxylate) to which oligopeptides can be attached have been investigated. A porphyrinyl amino-acid derivative has been synthesised by coupling a porphyrin monopropionate with phenylalanine methyl ester. Routes to pyrroles bearing butoxycarbonylaminoethyl side-chains via Curtius-type degradations, are described, and their potential for elaboration into porphyrins is discussed. The most promising bifunctional porphyrin with differentially protected amino and carboxylate side-chains was found to be the butoxycarbonylhydrazido methyl ester derivative of mesoporphyrin-II.
Publication Source (Journal or Book title)
Journal of the Chemical Society, Perkin Transactions 1
First Page
1441
Last Page
1448
Recommended Citation
Jackson, A., Kenner, G., Smith, K., & Suckling, C. (1982). Synthetic approaches to versatile hemoprotein model compounds built from porphyrins and peptides. Journal of the Chemical Society, Perkin Transactions 1, 1441-1448. https://doi.org/10.1039/p19820001441